This fatal neurodegenerative disorder is characterized by the selective loss of motor neurons in the spinal cord, brainstem and motor cortex. An estimated 30,000 Americans are living with ALS, and more than half of patients die within 2.5 years following the onset of symptoms. Preclinical findings have supported anecdotal reports by patients that medical cannabis may help in moderating the disease’s development and in alleviating pain, appetite loss, and depression.  Recent preclinical findings indicate that medical cannabis use might delay ALS progression and reduce symptom severity.

How Cannabis may help ALS:

  • Cannabis may potentially protect against neuropathy, decrease pain, and reduce muscle spasms.

  • Cannabis may also aid in palliative care, reducing anxiety and promoting sleep.


Cannabis and amyotrophic lateral sclerosis: hypothetical and practical applications, and a call for clinical trials.